Autocrine production of interleukin 1beta confers constitutive nuclear factor kappaB activity and chemoresistance in pancreatic carcinoma cell lines.

@article{Arlt2002AutocrinePO,
  title={Autocrine production of interleukin 1beta confers constitutive nuclear factor kappaB activity and chemoresistance in pancreatic carcinoma cell lines.},
  author={Alexander Arlt and Jens Vorndamm and Susanne Sebens M{\"u}erk{\"o}ster and Honggang Yu and Wolfgang Schmidt and Ulrich Robert Foelsch and Heiner Sch{\"a}fer},
  journal={Cancer research},
  year={2002},
  volume={62 3},
  pages={910-6}
}
We have recently shown that several pancreatic carcinoma cell lines are resistant to topoisomerase IIalpha inhibitors due to elevated basal nuclear factor kappaB (NF-kappaB) activity, and blockade of this activity by various means strongly increased chemosensitivity. In search of possible mechanisms leading to exaggerated NF-kappaB activity, we identified interleukin (IL)-1beta as a key mediator of this activation in two of the chemoresistant cell lines (A818-4 and PancTu-1). These cells… CONTINUE READING

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