Autocrine production of basic fibroblast growth factor translated from novel synthesized mRNA mediates thrombin-induced mitogenesis in smooth muscle cells.

@article{Cucina2002AutocrinePO,
  title={Autocrine production of basic fibroblast growth factor translated from novel synthesized mRNA mediates thrombin-induced mitogenesis in smooth muscle cells.},
  author={Alessandra Cucina and Valeria Borrelli and Marco Lucarelli and Antonio V Sterpetti and Antonino Giovanni Cavallaro and Roberto Strom and Luciana Santoro-D'Angelo and Sigfrido Scarpa},
  journal={Cell biochemistry and function},
  year={2002},
  volume={20 1},
  pages={
          39-46
        }
}
Thrombin is known to stimulate smooth muscle cell (SMC) growth in culture but the mechanisms underlying growth stimulation remain unclear. Previous works have observed a significant increase in platelet-derived growth factor AA and basic fibroblast growth factor (bFGF) release by bovine aortic SMC after addition of thrombin. The aim of this study was to clarify the link between thrombin, bFGF and SMC proliferation by examining the kinetics of autocrine production of bFGF by thrombin-stimulated… CONTINUE READING
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