Autocrine-paracrine regulation of human trophoblast invasiveness by insulin-like growth factor (IGF)-II and IGF-binding protein (IGFBP)-1.

@article{Hamilton1998AutocrineparacrineRO,
  title={Autocrine-paracrine regulation of human trophoblast invasiveness by insulin-like growth factor (IGF)-II and IGF-binding protein (IGFBP)-1.},
  author={Gregory S Hamilton and Jeffrey J. Lysiak and Victor K M Han and P. K. Lala},
  journal={Experimental cell research},
  year={1998},
  volume={244 1},
  pages={147-56}
}
Trophoblast growth and invasion of the uterus are tightly regulated by locally produced factors. Since insulin-like growth factor (IGF)-II is produced by the invasive human extravillous trophoblast (EVT) cells and IGF-binding protein (IGFBP)-1 by the decidual cells in situ that are in proximity to each other, we examined the possible influence of these molecules on proliferation, migration, and invasiveness of first-trimester EVT cells in culture. These EVT cell functions were respectively… CONTINUE READING
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