Autocrine or paracrine inflammatory actions of corticotropin-releasing hormone in vivo.

@article{Karalis1991AutocrineOP,
  title={Autocrine or paracrine inflammatory actions of corticotropin-releasing hormone in vivo.},
  author={Katia Karalis and Hideki Sano and Jonathon Redwine and Samuel J Listwak and Ronald L. Wilder and George P. Chrousos},
  journal={Science},
  year={1991},
  volume={254 5030},
  pages={421-3}
}
Corticotropin-releasing hormone (CRH) functions as a regulator of the hypothalamic-pituitary-adrenal axis and coordinator of the stress response. CRH receptors exist in peripheral sites of the immune system, and CRH promotes several immune functions in vitro. The effect of systemic immunoneutralization of CRH was tested in an experimental model of chemically induced aseptic inflammation in rats. Intraperitoneal administration of rabbit antiserum to CRH caused suppression of both inflammatory… CONTINUE READING

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