Autocrine nerve growth factor in human keratinocytes.

@article{Pincelli2000AutocrineNG,
  title={Autocrine nerve growth factor in human keratinocytes.},
  author={Carlo Pincelli and Alessandra Marconi},
  journal={Journal of dermatological science},
  year={2000},
  volume={22 2},
  pages={
          71-9
        }
}
Biologically active nerve growth factor (NGF) is synthesised and released by proliferating normal human keratinocytes. NGF up-regulates the expression of NGF mRNA in keratinocytes. Keratinocytes express both the low (p75)- and the high-affinity (TrkA) NGF-receptors, which are located in the basal layer of the epidermis. K252, a specific inhibitor of trk phosphorylation, blocks NGF-induced keratinocyte proliferation, in absence of exogenous NGF. Normal keratinocytes over-expressing TrkA… CONTINUE READING
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