Autocrine motility factor signaling induces tumor apoptotic resistance by regulations Apaf-1 and Caspase-9 apoptosome expression.

@article{Haga2003AutocrineMF,
  title={Autocrine motility factor signaling induces tumor apoptotic resistance by regulations Apaf-1 and Caspase-9 apoptosome expression.},
  author={Arayo Haga and Tatsuyoshi Funasaka and Yasufumi Niinaka and Avraham Raz and Hisamitsu Nagase},
  journal={International journal of cancer},
  year={2003},
  volume={107 5},
  pages={707-14}
}
Autocrine motility factor (AMF) is a cytokine that regulates locomotion and metastasis of tumor cells. It is well known that expression levels of AMF secretion and its receptor (AMF R) are closely related to tumor malignancy and rheumatoid arthritis. We have established that AMF signaling induced anti-apoptotic activity and that human fibrosarcoma HT-1080 line that secreted high levels of AMF were resistant to drug-induced apoptosis. These cells did not express the apoptotic protease activating… CONTINUE READING

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