Autocrine motility factor signaling enhances pancreatic cancer metastasis.

  title={Autocrine motility factor signaling enhances pancreatic cancer metastasis.},
  author={Soichi Tsutsumi and Takashi Yanagawa and Tatsuo Shimura and Hiroyuki Kuwano and Avraham Raz},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={10 22},
PURPOSE Autocrine motility factor (AMF)/phosphoglucose isomerase (PGI) is a ubiquitous cytosolic enzyme that plays a key role in glycolysis. AMF/PGI is also a multifunctional protein that acts in the extracellular milieu as a potent mitogen/cytokine. Increased expression of AMF/PGI and its receptor has been found in a wide spectrum of malignancies and is associated with cancer progression and metastasis. Recent studies indicated that AMF is induced by hypoxia and enhances the random motility of… CONTINUE READING


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Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer

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  • Pancreas
  • 2003
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