Autocrine motility factor modulates EGF-mediated invasion signaling.

  title={Autocrine motility factor modulates EGF-mediated invasion signaling.},
  author={Dhong Hyo Kho and Tianpeng Zhang and Vitaly Balan and Yi Wang and Seung-Wook Ha and Youming Xie and Avraham Raz},
  journal={Cancer research},
  volume={74 8},
Autocrine motility factor (AMF) enhances invasion by breast cancer cells, but how its secretion and effector signaling are controlled in the tumor microenvironment is not fully understood. In this study, we investigated these issues with a chimeric AMF that is secreted at high levels through a canonical endoplasmic reticulum (ER)/Golgi pathway. Using this tool, we found that AMF enhances tumor cell motility by activating AKT/ERK, altering actin organization, and stimulating β-catenin/TCF and… CONTINUE READING