Autocrine modulation of IL-8 production by sputum neutrophils in chronic bronchial sepsis.

@article{Pang1997AutocrineMO,
  title={Autocrine modulation of IL-8 production by sputum neutrophils in chronic bronchial sepsis.},
  author={G T Pang and Mercedes Sora Ortega and R Zighang and Glen Reeves and Robert Clancy},
  journal={American journal of respiratory and critical care medicine},
  year={1997},
  volume={155 2},
  pages={726-31}
}
We examined the activity of neutrophils isolated from sputum and blood of subjects with chronic bronchial sepsis in terms of interleukin-8 (IL-8), IL-1beta, and tumor necrosis factor-alpha (TNF alpha) production. In sputum, the numbers of neutrophils correlated with the concentrations of these cytokines. Sputum neutrophils constitutively secreted large amounts of IL-8, IL-1beta, and TNF alpha. The patterns of secretion, however, differed from those of blood neutrophils stimulated with bacterial… CONTINUE READING

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