Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells.

@article{Aoki2006AutocrineLB,
  title={Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells.},
  author={Hiroyoshi Aoki and Hirohide Ohnishi and Kouji Hama and Takako Ishijima and Yukihiro Satoh and Kazunobu Hanatsuka and Akira Ohashi and Shinichi Wada and Tomohiko Miyata and Hiroto Kita and Hironori Yamamoto and Hiroyuki Osawa and Kiichi Sato and Kiichi Tamada and Hiroshi Yasuda and Hirosato Mashima and Kentaro Sugano},
  journal={American journal of physiology. Cell physiology},
  year={2006},
  volume={290 4},
  pages={
          C1100-8
        }
}
Pancreatic stellate cells (PSCs) are activated during pancreatitis and promote pancreatic fibrosis by producing and secreting ECMs such as collagen and fibronectin. IL-1beta has been assumed to participate in pancreatic fibrosis by activating PSCs. Activated PSCs secrete various cytokines that regulate PSC function. In this study, we have examined IL-1beta secretion from culture-activated PSCs as well as its regulatory mechanism. RT-PCR and ELISA have demonstrated that PSCs express IL-1beta… CONTINUE READING

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