Autocrine inhibitory influences of alpha-melanocyte-stimulating hormone in malignant pleural mesothelioma.

@article{Catania2004AutocrineII,
  title={Autocrine inhibitory influences of alpha-melanocyte-stimulating hormone in malignant pleural mesothelioma.},
  author={Carmelina Anna Catania and Gualtiero I. Colombo and Andrea Carlin and Letizia Garofalo and Stefano Gatti and Roberto Buffa and Nadia Carboni and Lorenzo Rosso and Luigi Santambrogio and Luigi Cantalamessa and James Lipton},
  journal={Journal of leukocyte biology},
  year={2004},
  volume={75 2},
  pages={
          253-9
        }
}
Malignant pleural mesothelioma is a highly aggressive tumor arising from the mesothelial cells that line the pleural cavities. This tumor is resistant to most conventional anticancer treatments and appears to be very sensitive to growth-promoting influences of cytokines and growth factors. Identification of natural inhibitory pathways that control growth should aid discovery of novel therapeutic approaches. We hypothesized that alpha-melanocyte-stimulating hormone (alpha-MSH), which is produced… CONTINUE READING