Autocrine induction of collagenase by serum amyloid A-like and beta 2-microglobulin-like proteins.

@article{Brinckerhoff1989AutocrineIO,
  title={Autocrine induction of collagenase by serum amyloid A-like and beta 2-microglobulin-like proteins.},
  author={Constance E. Brinckerhoff and Teresa I Mitchell and M J Karmilowicz and Barbara Kluve-Beckerman and Merrill D L Benson},
  journal={Science},
  year={1989},
  volume={243 4891},
  pages={655-7}
}
Two autocrine proteins of 14 and 12 kilodaltons that induce the synthesis of rabbit fibroblast collagenase were identified. The proteins were purified from serum-free culture medium taken from rabbit synovial fibroblasts stimulated with phorbol myristate acetate. The amino-terminal sequences of the 14- and 12-kilodalton species were approximately 60 to 80 percent homologous with serum amyloid A and beta 2 microglobulin, respectively. The polyacrylamide gel-eluted proteins retained the ability… CONTINUE READING

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