Autocrine hGH stimulates oncogenicity, epithelial-mesenchymal transition and cancer stem cell-like behavior in human colorectal carcinoma

@inproceedings{Wang2017AutocrineHS,
  title={Autocrine hGH stimulates oncogenicity, epithelial-mesenchymal transition and cancer stem cell-like behavior in human colorectal carcinoma},
  author={J G Wang and Qing-Yun Chong and Xin-Bao Sun and Ming-Liang You and Vijay Pandey and Yi-Jun Chen and Qiu-Shi Zhuang and Dong-Xu Liu and Lan Ma and Zheng-Sheng Wu and Tao Zhu and Peter E. Lobie},
  booktitle={Oncotarget},
  year={2017}
}
Tumor derived human growth hormone (hGH) has been implicated in cancer development and progression. However, the specific functional role of autocrine/paracrine hGH in colorectal cancer (CRC) remains largely to be determined. Herein, we demonstrated a crucial oncogenic role of autocrine hGH in CRC progression. Elevated hGH expression was detected in CRC compared to normal colorectal tissue, and hGH expression in CRC was positively associated with tumor size and lymph node metastasis. Forced… CONTINUE READING