Autocrine glutamate signaling promotes glioma cell invasion.

  title={Autocrine glutamate signaling promotes glioma cell invasion.},
  author={Susan A. Lyons and Wook Joon Chung and Amy K. Weaver and Toyin Adeyemi Ogunrinu and Harald Sontheimer},
  journal={Cancer research},
  volume={67 19},
Malignant gliomas have been shown to release glutamate, which kills surrounding brain cells, creating room for tumor expansion. This glutamate release occurs primarily via system xC, a Na+-independent cystine-glutamate exchanger. We show here, in addition, that the released glutamate acts as an essential autocrine/paracrine signal that promotes cell invasion. Specifically, chemotactic invasion and scrape motility assays each show dose-dependent inhibition of cell migration when glutamate… CONTINUE READING


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