Autocrine control of glioma cells adhesion and migration through IRE1α-mediated cleavage of SPARC mRNA.

@article{Dejeans2012AutocrineCO,
  title={Autocrine control of glioma cells adhesion and migration through IRE1α-mediated cleavage of SPARC mRNA.},
  author={Nicolas Dejeans and Olivier Pluquet and St{\'e}phanie Lhomond and Florence Grise and Marion Bouchecareilh and Am{\'e}lie Juin and Maud Meynard-Cadars and Aur{\'e}lien Bidaud-Meynard and Catherine Gentil and Violaine Moreau and Fr{\'e}d{\'e}ric Saltel and Eric Chevet},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 18},
  pages={4278-87}
}
The endoplasmic reticulum (ER) is an organelle specialized for the folding and assembly of secretory and transmembrane proteins. ER homeostasis is often perturbed in tumor cells because of dramatic changes in the microenvironment of solid tumors, thereby leading to the activation of an adaptive mechanism named the unfolded protein response (UPR). The activation of the UPR sensor IRE1α has been described to play an important role in tumor progression. However, the molecular events associated… CONTINUE READING

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