Autocrine catecholamine biosynthesis and the beta-adrenoceptor signal promote pigmentation in human epidermal melanocytes.

@article{Gillbro2004AutocrineCB,
  title={Autocrine catecholamine biosynthesis and the beta-adrenoceptor signal promote pigmentation in human epidermal melanocytes.},
  author={Johanna M Gillbro and Lee K Marles and Nigel A. Hibberts and Karin Uta Schallreuter},
  journal={The Journal of investigative dermatology},
  year={2004},
  volume={123 2},
  pages={346-53}
}
Earlier it has been shown that human proliferating/undifferentiated basal keratinocytes hold the full capacity for autocrine catecholamine synthesis/degradation and express beta2-adrenoceptors (beta2-AR). In this report, we show that human melanocytes also express all of the mRNA and enzymes for autocrine synthesis of norepinephrine but fail to produce epinephrine. So far, it was established that human melanocytes express alpha1-AR which are induced by norepinephrine yielding the inosine… CONTINUE READING

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