Autocrine anti-apoptotic and proliferative effects of insulin in pancreatic beta-cells.

@article{Muller2006AutocrineAA,
  title={Autocrine anti-apoptotic and proliferative effects of insulin in pancreatic beta-cells.},
  author={Dany S. Muller and Peter Martin Jones and Shanta J Persaud},
  journal={FEBS letters},
  year={2006},
  volume={580 30},
  pages={6977-80}
}
Insulin and glucose inhibited apoptosis in the MIN6 insulin-secreting cell line. The protective effect of 25 mM glucose was prevented by an anti-insulin antibody and this antibody-induced increase in apoptosis was reversed by the presence of excess insulin. Glucose stimulated MIN6 cell proliferation and this was inhibited by blockade of insulin secretion, by an anti-insulin antibody and by phosphatidylinositol-3 kinase (PI-3K) inhibition. Furthermore, MIN6 cell proliferation was stimulated by… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Similar Papers

Loading similar papers…