Autocrine and paracrine actions of natriuretic peptides in the heart.

  title={Autocrine and paracrine actions of natriuretic peptides in the heart.},
  author={Savio P D'Souza and Martin A. Davis and Gary F. Baxter},
  journal={Pharmacology & therapeutics},
  volume={101 2},
The natriuretic peptides, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), are a family of polypeptide mediators exerting numerous actions in cardiovascular homeostasis. ANP and BNP are cardiac derived, being secreted and up-regulated in myocardium in response to many pathophysiological stimuli. CNP is an endothelium-derived mediator. The classical endocrine effects of ANP and BNP on fluid homeostasis and blood pressure, especially in… CONTINUE READING
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