Autocrine activation of cultured macrophages by brain-derived neurotrophic factor.

  title={Autocrine activation of cultured macrophages by brain-derived neurotrophic factor.},
  author={Toshio Asami and Takuya Ito and Hidefumi Fukumitsu and Hiroshi Nomoto and Yoshiko Furukawa and Shoei Furukawa},
  journal={Biochemical and biophysical research communications},
  volume={344 3},
To elucidate a significance of the expression of brain-derived neurotrophic factor (BDNF) in the activated microglia/macrophages of the injured central nervous system, we examined BDNF actions on or BDNF synthesis by macrophages cultured from the mouse peritoneal cavity. They synthesized BDNF and neurotrophin-3 (NT-3) in addition to expressing high-affinity neurotrophin receptors, full-length TrkB (FL), truncated TrkB (TK(-)), and TrkC, thus suggesting an autocrine influence of BDNF and NT-3… CONTINUE READING
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