Autocrine activation by interleukin 1alpha induces the fibrogenic phenotype of systemic sclerosis fibroblasts.

@article{Kawaguchi2004AutocrineAB,
  title={Autocrine activation by interleukin 1alpha induces the fibrogenic phenotype of systemic sclerosis fibroblasts.},
  author={Yasushi Kawaguchi and Susan A. McCarthy and Simon C. Watkins and Timothy M. Wright},
  journal={The Journal of rheumatology},
  year={2004},
  volume={31 10},
  pages={1946-54}
}
OBJECTIVE To explore the cellular localization of interleukin 1alpha (IL-1alpha) in cultured fibroblasts from lesional skin of patients with systemic sclerosis (SSc) and to study the role of intracellular IL-1alpha in the activation of fibroblasts. METHODS Dermal fibroblasts were derived from 12 patients with SSc. Expression of IL-1alpha mRNA was examined using reverse transcriptase-polymerase chain reaction (RT-PCR). The cellular distribution of IL-1alpha was examined by subcellular… CONTINUE READING