Autocrine VEGF signaling promotes proliferation of neoplastic Barrett's epithelial cells through a PLC-dependent pathway.

@article{Zhang2014AutocrineVS,
  title={Autocrine VEGF signaling promotes proliferation of neoplastic Barrett's epithelial cells through a PLC-dependent pathway.},
  author={Qiuyang Zhang and Chunhua Yu and Sui Peng and Hao Xu and Ellen Wright and X. I. Zhang and Xiaofang Huo and Edaire Cheng and Thai H. Pham and Kiyotaka Asanuma and Kimmo J. Hatanpaa and Davood Rezai and David Wang and Venetia Rumnong Sarode and Shelby D. Melton and R M Genta and Stuart Spechler and Rhonda F Souza},
  journal={Gastroenterology},
  year={2014},
  volume={146 2},
  pages={461-72.e6}
}
BACKGROUND & AIMS Tumor cells express vascular endothelial growth factor (VEGF), which induces angiogenesis. VEGF also activates VEGF receptors (VEGFRs) on or within tumor cells to promote their proliferation in an autocrine fashion. We studied the mechanisms of autocrine VEGF signaling in Barrett's esophagus cells. METHODS Using Barrett's epithelial cell… CONTINUE READING