Autocrine PDGF stimulation in malignancies

Abstract

Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of mesenchymal cells, which have important functions during the embryonal development and in the adult during wound healing and tissue homeostasis. In tumors, PDGF isoforms are often over-expressed and contribute to the growth of both normal and malignant cells. This… (More)
DOI: 10.3109/03009734.2012.658119

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