Autocrine IL-12 is involved in dendritic cell modulation via CD40 ligation.

@article{Bianchi1999AutocrineII,
  title={Autocrine IL-12 is involved in dendritic cell modulation via CD40 ligation.},
  author={Roberta Bianchi and Ursula Grohmann and Carmine Vacca and Maria Laura Belladonna and Maria Cristina Fioretti and Paolo Puccetti},
  journal={Journal of immunology},
  year={1999},
  volume={163 5},
  pages={2517-21}
}
Ligation of CD40 on dendritic cells (DC) triggers production of IL-12. Using an adoptive transfer model we have previously shown that rIL-12 acts directly on DC to enhance presentation of an otherwise poorly immunogenic tumor peptide. Using the same experimental model, we now describe a similar adjuvanticity of CD40 ligation on peptide presentation by DC… CONTINUE READING