Autocrine IL-12 is involved in dendritic cell modulation via CD40 ligation.

Abstract

Ligation of CD40 on dendritic cells (DC) triggers production of IL-12. Using an adoptive transfer model we have previously shown that rIL-12 acts directly on DC to enhance presentation of an otherwise poorly immunogenic tumor peptide. Using the same experimental model, we now describe a similar adjuvanticity of CD40 ligation on peptide presentation by DC… (More)

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Cite this paper

@article{Bianchi1999AutocrineII, title={Autocrine IL-12 is involved in dendritic cell modulation via CD40 ligation.}, author={Roberta Bianchi and Ursula Grohmann and Carmine Vacca and Maria Laura Belladonna and Maria Cristina Fioretti and Paolo Puccetti}, journal={Journal of immunology}, year={1999}, volume={163 5}, pages={2517-21} }