Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced in diabetic retinopathy.

@article{Nawaz2013AutocrineCC,
  title={Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced in diabetic retinopathy.},
  author={Mohd Imtiaz Nawaz and Katrien Van Raemdonck and G. M. Shadab Mohammad and Dustan Kangave and Jo Van Damme and Ahmed M Abu El-Asrar and Sofie Struyf},
  journal={Experimental eye research},
  year={2013},
  volume={109},
  pages={
          67-76
        }
}
This study aimed at examining the presence and role of chemokines (angiogenic CCL2/MCP-1 and angiostatic CXCL4/PF-4, CXCL9/Mig, CXCL10/IP-10) in proliferative diabetic retinopathy (PDR). Regulated chemokine production in human retinal microvascular cells (HRMEC) and chemokine levels in vitreous samples from 40 PDR and 29 non-diabetic patients were analyzed. MCP-1, PF-4, Mig, IP-10 and VEGF levels in vitreous fluid from PDR patients were significantly higher than in controls. Except for IP-10… CONTINUE READING
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