Autocrine/paracrine regulation of keratinocyte urokinase plasminogen activator through the TGF‐α/EGF receptor

@article{Jensen1993AutocrineparacrineRO,
  title={Autocrine/paracrine regulation of keratinocyte urokinase plasminogen activator through the TGF‐$\alpha$/EGF receptor},
  author={Pamela J. Jensen and Ulrich Rodeck},
  journal={Journal of Cellular Physiology},
  year={1993},
  volume={155}
}
Transforming growth factor‐α (TGF‐α) appears to be an important autocrine/paracrine regulator of keratinocyte function. Not only does TGF‐α induce keratinocyte proliferation and migration in vitro, but it also has been detected in normal human epidermis and at elevated levels in hyperproliferative epidermis. In the present study we report that exogenous TGF‐α increases urokinase‐type plasminogen activator (uPA) in cultured human keratinocytes. Furthermore, in the absence of exogenous growth… 
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