Autocrine/paracrine proliferative effect of ovarian GH and IGF-I in chicken granulosa cell cultures.

@article{AhumadaSolrzano2016AutocrineparacrinePE,
  title={Autocrine/paracrine proliferative effect of ovarian GH and IGF-I in chicken granulosa cell cultures.},
  author={S Marisela Ahumada-Sol{\'o}rzano and Carlos Guillermo Mart{\'i}nez-Moreno and Martha I Carranza and Jos{\'e} {\'A}vila-Mendoza and Jos{\'e} Luis Luna-Acosta and Maricela Luna and Carlos Ar{\'a}mburo},
  journal={General and comparative endocrinology},
  year={2016},
  volume={234},
  pages={
          47-56
        }
}
It is known that growth hormone (GH) and its receptor (GHR) are expressed in granulosa cells (GC) and thecal cells during the follicular development in the hen ovary, which suggests GH is involved in autocrine/paracrine actions in the female reproductive system. In this work, we show that the knockdown of local ovarian GH with a specific cGH siRNA in GC cultures significantly decreased both cGH mRNA expression and GH secretion to the media, and also reduced their proliferative rate. Thus, we… CONTINUE READING
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