Autocatalytic processing of recombinant human procathepsin B is a bimolecular process.

@article{Rozman1999AutocatalyticPO,
  title={Autocatalytic processing of recombinant human procathepsin B is a bimolecular process.},
  author={Janez Rozman and Jure Stojan and R Kuhelj and Vito Turk and Boris Turk},
  journal={FEBS letters},
  year={1999},
  volume={459 3},
  pages={358-62}
}
Cathepsin B and other lysosomal cysteine proteinases are synthesized as inactive zymogens, which are converted to their mature forms by other proteases or by autocatalytic processing. Procathepsin B autoactivation was shown in vitro at pH 4.5 to be a bimolecular process with K(s) and k(cat) values of 2.1+/-0.9 microM and 0.12+/-0.02 s(-1)6.0. However, in the presence of 0.5 microg/ml of dextran sulfate, relatively rapid processing is observed even at pH 6.5 (t(1/2) approximately 90 min… CONTINUE READING

From This Paper

Topics from this paper.
25 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…