Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif.

@article{Lin2004AutocatalyticCO,
  title={Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif.},
  author={Hsi-Hsien Lin and Gin-Wen Chang and John Q Davies and Martin Stacey and James Harris and Siamon Gordon},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 30},
  pages={31823-32}
}
Post-translational cleavage at the G protein-coupled receptor proteolytic site (GPS) has been demonstrated in many class B2 G protein-coupled receptors as well as other cell surface proteins such as polycystin-1. However, the mechanism of the GPS proteolysis has never been elucidated. Here we have characterized the cleavage of the human EMR2 receptor and identified the molecular mechanism of the proteolytic process at the GPS. Proteolysis at the highly conserved His-Leu downward arrow Ser(518… CONTINUE READING