Autoassemblies of α-Cyclodextrin and Grafted Polysaccharides: Crystal Structure and Specific Properties of the Platelets.

  title={Autoassemblies of $\alpha$-Cyclodextrin and Grafted Polysaccharides: Crystal Structure and Specific Properties of the Platelets.},
  author={Florent Carn and Sophie Nowak and Ismail Chaab and Raul Diaz‐Salmeron and Madeleine Djabourov and Kawthar Bouchemal},
  journal={The journal of physical chemistry. B},
  volume={122 22},
Cyclodextrins (CDs) are a family of oligosaccharides with a toroid shape, which exhibit a remarkable ability to include guest molecules in their internal cavity, providing a hydrophobic environment for poorly soluble molecules. Recently, new types of inclusions of α CDs with alkyl grafted polysaccharide chains (pullulan, chitosan, dextran, amylopectin, chondroitin sulfate...) have been prepared which are autoassembled into micro- and nanoplatelets. We report in this paper an extensive… 
Formation of well-defined supramolecular microstructures consisting of γ-cyclodextrin and polyether —rods, cubes, plates, and nanosheets—guided by guest polymer structure
Abstract To construct well-defined microstructures, strict controls of the temperature and sophisticated techniques are generally required because microstructure formation is usually based on
New insights on the structure of hexagonally faceted platelets from hydrophobically modified chitosan and &agr;‐cyclodextrin
It is demonstrated that fatty acid/&agr;‐cyclodextrin interaction is the driving force for platelet formation and revealed for the first time that a simple magnetic mixing of fatty acids with &agr ;‐cyclodesxtrin in water results from solid inclusion complexes with a crystalline structural organization characterized by powder X‐ray diffraction.
Hierarchical supramolecular platelets from hydrophobically‐modified polysaccharides and &agr;‐cyclodextrin: Effect of hydrophobization and &agr;‐cyclodextrin concentration on platelet formation
This is the first report showing the possibility to control platelet formation by modifying DS and &agr;‐cyclodextrin concentration, independently on polysaccharide composition.
Grafted cyclodextrin as carrier for control drug delivery and efficient cell killing.
The cell killing efficiency has been demonstrated by embedding anticancer drug in polymer matrices causing mortality rate of 75% using graft copolymer against scanty 25% using pure drug or drug embedded in CD and the result is understood from the sustained release of drug from the graftCopolymer vis-à-vis burst release in other systems.
Highly Regulated Supramolecular Assembly of 2-O-Methylated α-Cyclodextrin to Construct Vertically Oriented Microrods on Graphite.
A simple precipitation technique with common solvents forms supramolecular microstructures with highly regulated molecular arrangements from a methylated derivative of α-cyclodextrin at the 2-O position to provide insight into the design of supramolescular building blocks for controlled self-assembly.
Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers
Different combinations of cyclodextrin platform conjugated with polymers is considered as drug delivery systems with synergetic effect that improves solubility, targeting and biocompatibility of formulations.
Supramolecular assembly of calix[4]resorcinarenes and chitosan for the design of drug nanocontainers with selective effects on diseased cells
In this paper, the spontaneous formation of nanoparticles through supramolecular interactions between chitosan and sulfonated calix[4]resorcinarenes was demonstrated. A set of physical–chemical
Hierarchically built hyaluronan nano‐platelets have symmetrical hexagonal shape, flattened surfaces and controlled size
This is the first report showing the design of non‐spherical and flattened HA nano‐platelets that could be used to study the impact of nanomaterial shape on molecular interactions with cells.
Combination of amphotericin B and chitosan platelets for the treatment of experimental cutaneous leishmaniasis: Histological and immunohistochemical examinations
Abstract Cutaneous leishmaniasis (CL) is a chronic infectious disease caused by protozoa of the genus Leishmania. Although amphotericin B-deoxycholate (AmB-DOC) showed its ability to partially cure
Formation of Isolated Pseudo-Polyrotaxane Nanosheet Consisting of α-Cyclodextrin and Poly(ethylene glycol)
Nanosheet materials have recently attracted the attention of researchers because of their unique physical properties. In the present study, we have reported a novel methodology to fabricate isolate...


Dehydration, dissolution, and melting of cyclodextrin crystals.
Thermogravimetric measurements identify various binding sites of water and highlight the difference between the crystals equilibrated under various humid atmospheres, and establish the limit of solubility versus temperature and measure for the first time the melting temperatures of the hydrated crystals.
Pickering emulsions with α-cyclodextrin inclusions: Structure and thermal stability.
An important feature observed in the emulsions with micro-platelets is the partial substitution of the guest molecules occurring at room temperature at the oil/water interfaces without dissolution, possibly by a diffusion mechanism of the oil.
Topography of cyclodextrin inclusion complexes
A correlation exists between the type of inclusion complex and the volume required for a complex molecule: 1200–≈ 1400 A 3 for molecular guests, and 1400–1500 A3 for ionic guests.
Solid-State Complexation of Poly(Ethylene Glycol) with α−Cyclodextrin
Low-molecular-weight liquid poly(ethylene glycol) (PEG) spontaneously forms an inclusion compound (IC) when combined with α-cyclodextrin (α-CD) powder at room temperature. This process can be
Electron microscopic observations of inclusion complexes of α-, β-, and γ-cyclodextrins
Abstract Inclusion complexes of α-, β-, and γ-cyclodextrins (α-, β-, and γ-CyDs) were prepared with poly(ethylene oxide) (PEO), poly(propylene oxide) (PPO), and poly(ethylene adipate) (PEA),
Two-Phase Channel Structures Based on α-Cyclodextrin−Polyethylene Glycol Inclusion Complexes
Wide-angle X-ray scattering observations of α-cyclodextrin (CD)−poly(ethylene glycol) (PEG) inclusion complexes (ICs) have shown for the first time that two crystalline columnar modifications (forms
Cyclodextrin Inclusion Compounds in Research and Industry
α-, β-, and γ-Cyclodextrins are cyclic oligosaccharides consisting of six, seven, or eight glucose units, which can be obtained on a large scale from starch. They form inclusion compounds with
Self-assembled cyclodextrin aggregates and nanoparticles.
Formation of CD aggregates and CD nanoparticles is reviewed with emphasis on the physicochemical properties of self-assembled CDs and CD complexes.
Self-assembling microparticles with controllable disruption properties based on cyclodextrin interactions.
In this paper, we present the formation of particles by self-assembly of cyclodextrin polymers and hydrophobically modified dextran followed by a controlled disruption of the particles by addition of
A highly hydrated α-cyclodextrin/1-undecanol inclusion complex: crystal structure and hydrogen-bond network from high-resolution neutron diffraction at 20 K.
This is the first study that analyses the entire hydrogen-bonding network involved in the formation of a cyclodextrin dimer surrounded by its shell of water molecules, and it shows that the lack of compactness of this crystal form is related to the high number of interstitial water molecules.