Autoantigens ADAMTSL5 and LL37 are significantly upregulated in active Psoriasis and localized with keratinocytes, dendritic cells and other leukocytes.

@article{FuentesDuculan2017AutoantigensAA,
  title={Autoantigens ADAMTSL5 and LL37 are significantly upregulated in active Psoriasis and localized with keratinocytes, dendritic cells and other leukocytes.},
  author={Judilyn Fuentes-Duculan and Kathleen M. Bonifacio and Jason E Hawkes and Norma Kunjravia and Inna Cueto and Xuan Li and J. Seoane Gonzalez and Sandra Garcet and James G. Krueger},
  journal={Experimental dermatology},
  year={2017},
  volume={26 11},
  pages={
          1075-1082
        }
}
Psoriasis is a common immune-mediated disease that affects 2%-4% of individuals in North America and Europe. In the past decade, advances in research have led to an improved understanding of immune pathways involved in the pathogenesis of psoriasis and has spurred the development of targeted therapeutics. Recently, three psoriasis autoantigens have been described: cathelicidin (LL37), a disintegrin and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5), and lipid… CONTINUE READING
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