Autoantibody to an immunoregulatory inducer population in patients with juvenile rheumatoid arthritis.

@article{Morimoto1981AutoantibodyTA,
  title={Autoantibody to an immunoregulatory inducer population in patients with juvenile rheumatoid arthritis.},
  author={Chikao Morimoto and Ellis L. Reinherz and Yves Borel and Evangelia C. Mantzouranis and AlfredD. Steinberg and StuartF. Schlossman},
  journal={The Journal of clinical investigation},
  year={1981},
  volume={67 3},
  pages={
          753-61
        }
}
The human inducer (T4(+)) and reciprocal cytotoxic/suppressor (T5(+)/T8(+)) subsets have been defined by monoclonal antibodies. In the present study, we examined the relationship of naturally occurring anti-T cell autoantibodies found in patients with active juvenile rheumatoid arthritis (JRA) to these subsets. In one approach, normal T cells were treated with anti-T4 or anti-T8 to eliminate the corresponding subset of cells and then analyzed for reactivity with JRA sera. It was found that JRA… CONTINUE READING

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