Autoantibody-mediated atherosclerosis.

  title={Autoantibody-mediated atherosclerosis.},
  author={Eiji Matsuura and Kazuko Kobayashi and T. Koike and Yehuda Shoenfeld},
  journal={Autoimmunity reviews},
  volume={1 6},
Beta2-glycoprotein I (beta2-GPI) is a major antigen for antiphospholipid antibodies (aPL) present in patients with antiphospholipid syndrome (APS). Oxidized low-density lipoprotein (oxLDL) is subsequently targeted by beta2-GPI and anti-beta2-GPI autoantibodies. Ligands specific for beta2-GPI derived from oxLDL have been characterized as oxidized forms of cholesteryl linoleate, such as 7-ketocholesterol-9-carboxynonanoate, i.e. 9-oxo-9-(7-ketocholest-5-en-3beta-yloxy) nonanoic acid, (namely… CONTINUE READING


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