Autoantibody against N(epsilon)-(carboxymethyl)lysine: an advanced glycation end product of the Maillard reaction.

@article{Shibayama1999AutoantibodyAN,
  title={Autoantibody against N(epsilon)-(carboxymethyl)lysine: an advanced glycation end product of the Maillard reaction.},
  author={Rina Shibayama and Nobukazu Araki and Ryoji Nagai and Seikoh Horiuchi},
  journal={Diabetes},
  year={1999},
  volume={48 9},
  pages={1842-9}
}
Prolonged incubation of proteins with reducing sugar produces advanced glycation end products (AGEs), which are implicated as factors for aging and diabetic complications. We previously demonstrated the presence of N(epsilon)-(carboxymethyl)lysine (CML), one of the main AGE structures, in human and animal tissues using a monoclonal anti-CML antibody (6D12). These findings suggest that CML structures present in vivo could serve as immunogens to generate autoantibodies. This suggestion was tested… CONTINUE READING

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