Autoantibody Profiling in Lupus Patients using Synthetic Nucleic Acids

@inproceedings{Kleka2018AutoantibodyPI,
  title={Autoantibody Profiling in Lupus Patients using Synthetic Nucleic Acids},
  author={Martin Kle{\vc}ka and Christina Thybo and Claudia Macaubas and Ilia A. Solov'yov and Julia F Simard and Imelda Maria Balboni and Emily M. Fox and Anne Lise Voss and Elizabeth D Mellins and Kira Astakhova},
  booktitle={Scientific Reports},
  year={2018}
}
Autoantibodies to nuclear components of cells (antinuclear antibodies, ANA), including DNA (a-DNA), are widely used in the diagnosis and subtyping of certain autoimmune diseases, including systemic lupus erythematosus (SLE). Despite clinical use over decades, precise, reproducible measurement of a-DNA titers remains difficult, likely due to the substantial sequence and length heterogeneity of DNA purified from natural sources. We designed and tested a panel of synthetic nucleic acid molecules… CONTINUE READING
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