Autoantibodies to tumor-associated antigens combined with abnormal alpha-fetoprotein enhance immunodiagnosis of hepatocellular carcinoma.

@article{Chen2010AutoantibodiesTT,
  title={Autoantibodies to tumor-associated antigens combined with abnormal alpha-fetoprotein enhance immunodiagnosis of hepatocellular carcinoma.},
  author={Yao Chen and Yusen Zhou and Suimin Qiu and Kaijuan Wang and Siwei Liu and Xuan-Xian Peng and Junfeng Li and Eng M Tan and Jianying Zhang},
  journal={Cancer letters},
  year={2010},
  volume={289 1},
  pages={32-9}
}
The identification and characterization of tumor-associated antigens (TAAs) and their use in antigen mini-arrays for cancer immunodiagnosis has been of interest recently as an approach to cancer detection. In this study, autoantibodies in sera from a patient with HCC were used as probes to immunoscreen a HepG2 cDNA expression library for the identification of TAAs involved in malignant liver transformation. Recombinant proteins from two genes identified in this manner, Sui1 and RalA were… CONTINUE READING