Autoantibodies to the high-affinity IgE receptor in chronic urticaria: how important are they?

  title={Autoantibodies to the high-affinity IgE receptor in chronic urticaria: how important are they?},
  author={Javed Alam Sheikh},
  journal={Current Opinion in Allergy and Clinical Immunology},
  • J. Sheikh
  • Published 1 October 2005
  • Medicine, Biology
  • Current Opinion in Allergy and Clinical Immunology
Purpose of reviewEighty to 90% of patients with chronic urticaria have no specific external cause for their disease, which is therefore labeled ‘chronic idiopathic urticaria’. We now know, however, that as many as 30–50% of patients have evidence of an autoantibody to the high-affinity receptor for IgE (FcϵRI), which may be pathogenic. The exact prevalence and role of these autoantibodies is still under investigation. Recent findingsThe frequency of autoantibodies to FcϵRI in chronic urticaria… 

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