Autoantibodies to the high-affinity IgE receptor in chronic urticaria: how important are they?

@article{Sheikh2005AutoantibodiesTT,
  title={Autoantibodies to the high-affinity IgE receptor in chronic urticaria: how important are they?},
  author={Javed Alam Sheikh},
  journal={Current Opinion in Allergy and Clinical Immunology},
  year={2005},
  volume={5},
  pages={403–407}
}
  • J. Sheikh
  • Published 2005
  • Medicine
  • Current Opinion in Allergy and Clinical Immunology
Purpose of reviewEighty to 90% of patients with chronic urticaria have no specific external cause for their disease, which is therefore labeled ‘chronic idiopathic urticaria’. We now know, however, that as many as 30–50% of patients have evidence of an autoantibody to the high-affinity receptor for IgE (FcϵRI), which may be pathogenic. The exact prevalence and role of these autoantibodies is still under investigation. Recent findingsThe frequency of autoantibodies to FcϵRI in chronic urticaria… Expand
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  • Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2008
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Basophil responsiveness in chronic urticaria
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  • Medicine
  • Current allergy and asthma reports
  • 2009
TLDR
In active chronic idiopathic urticaria (CIU) subjects, changes in IgE receptor-signaling molecule expression levels accompany the altered degranulation function in blood basophils, and the arrival of therapies targeting IgE has shown that alteredBlood basophil de granulation behavior has potential use as a disease biomarker in CIU. Expand
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Alternative agent use and antihistamine refractoriness appear to place patients at increased risk for recurrence compared with first-line agent use alone. Expand
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Cyclosporin A, even in low-doses, can be an effective and short-term treat- ment with minimum side-effects in patients with AIU. Expand
The autologous serum skin test in a cohort of chronic idiopathic urticaria patients compared to respiratory allergy patients and healthy individuals
TLDR
The ASST is regarded as a reliable in vivo test in chronic idiopathic urticaria patients, with diagnostic, therapeutic and prognostic implications, however, positive ASST results have also occasionally been demonstrated in patients with other diseases and in healthy subjects. Expand
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