Autoantibodies to proteinase 3 and myeloperoxidase in systemic sclerosis.

  title={Autoantibodies to proteinase 3 and myeloperoxidase in systemic sclerosis.},
  author={Amelia Ruffatti and Renato A Sinico and Antonella Radice and Elena Ossi and Franco Cozzi and M Tonello and Panagiotis Grypiotis and Silvano Todesco},
  journal={The Journal of rheumatology},
  volume={29 5},
OBJECTIVE We evaluated the prevalence and clinical significance of proteinase 3 (PR3-) and myeloperoxidase (MPO-) antineutrophil cytoplasmic antibodies (ANCA) in 115 patients with systemic sclerosis (SSc, scleroderma). METHODS Sera were assayed by 2 independent centers, which used indirect immunofluorescence (IIF) and direct ELISA as screening tests. Inhibition-ELISA for PR3- and MPO-ANCA and PR3 capture-ELISA experiments were also performed. The clinical features of the ANCA positive were… CONTINUE READING
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