Autoantibodies to p53 in ovarian cancer patients and healthy women: a comparison between whole p53 protein and 18-mer peptides for screening purposes.

@article{Vennegoor1997AutoantibodiesTP,
  title={Autoantibodies to p53 in ovarian cancer patients and healthy women: a comparison between whole p53 protein and 18-mer peptides for screening purposes.},
  author={Claus Vennegoor and Hans W Nijman and Jan Wouter Drijfhout and Leen N. Vernie and Rob A Verstraeten and Silvia von Mensdorff-Pouilly and Jo Hilgers and Ren{\'e} H. M. Verheijen and W. Martin Kast and Cornelis J M Melief and Peter Kenemans},
  journal={Cancer letters},
  year={1997},
  volume={116 1},
  pages={93-101}
}
Autoantibodies against complete p53 protein and 18-mer peptides of p53 in ovarian cancer patients and healthy women were examined. Sera from 9% (4/46) of ovarian cancer patients but none (0/51) of healthy women recognized complete p53 protein. The antibodies were mainly of the IgG1 isotype. Two patients had also IgG2 antibodies. Sera from 28% (13/46) of cancer patients and 21% (11/52) of healthy women contained either IgM, or IgM plus IgG2 antibodies against 18-mer p53 peptides. Screening… CONTINUE READING

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