Autoantibodies to osteopontin in patients with osteoarthritis and rheumatoid arthritis.

@article{Sakata2001AutoantibodiesTO,
  title={Autoantibodies to osteopontin in patients with osteoarthritis and rheumatoid arthritis.},
  author={Muneyuki Sakata and Junichirou Tsuruha and Kayo Masuko-hongo and Hiroshi Nakamura and Toshimichi Matsui and Akihiro Sudo and Kusuya Nishioka and Tomohiro Kato},
  journal={The Journal of rheumatology},
  year={2001},
  volume={28 7},
  pages={
          1492-5
        }
}
OBJECTIVE Osteopontin (OPN), secreted mainly from chondrocytes, is suggested to be involved in the ossification and remodeling of bone and also in regulation of cytokine profiles. We investigated whether patients with osteoarthritis (OA) and rheumatoid arthritis (RA) display autoimmunity against OPN. METHODS Recombinant human OPN (rhOPN) was prepared as a fusion protein with beta-galactosidase using E. coli. Serum samples from patients with OA or RA and from age matched healthy donors were… CONTINUE READING

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