Autoantibodies to glutamate receptor subunit GluR2 in nonfamilial olivopontocerebellar degeneration

@article{Gahring1997AutoantibodiesTG,
  title={Autoantibodies to glutamate receptor subunit GluR2 in nonfamilial olivopontocerebellar degeneration},
  author={Lorise C Gahring and Scott W. Rogers and Roy E. Twyman},
  journal={Neurology},
  year={1997},
  volume={48},
  pages={494 - 500}
}
Article abstract-We describe a 63-year-old man with a 5-year history of progressive sporadic olivopontocerebellar atrophy (OPCA) who exhibits high serum titers of IgM autoantibodies to the neuronal glutamate receptor subunit GluR2. Immunohistochemistry revealed intense staining of mouse cerebellar Purkinje cells and cells in the pontine nuclei and olivary complex. Glutamate receptor currents were activated in a subset of cultured mouse neurons by an anti-GluR2 IgM fraction, and they were… 

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