Autoantibodies to glucosylated proteins in the plasma of patients with diabetes mellitus.

@article{Witztum1984AutoantibodiesTG,
  title={Autoantibodies to glucosylated proteins in the plasma of patients with diabetes mellitus.},
  author={Joseph L. Witztum and Urs P. Steinbrecher and Y A Kesaniemi and Martin J Fisher},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 10},
  pages={3204-8}
}
Nonenzymatic glucosylation interferes with recognition of low density lipoprotein (LDL) by its receptor and markedly decreases the rate of plasma clearance of glucosylated LDL, both in experimental animals and in normal human subjects. However, in selected diabetic subjects we have observed a paradoxical increase in the clearance of glucosylated LDL… CONTINUE READING