Autoantibodies to components of the mitotic apparatus
@article{Rattner2004AutoantibodiesTC, title={Autoantibodies to components of the mitotic apparatus}, author={Jerome B. Rattner and Gary J. Mack and Marvin J. Fritzler}, journal={Molecular Biology Reports}, year={2004}, volume={25}, pages={143-155} }
Autoantibodies directed to a variety of cellular antigens and organelles are a feature of autoimmune diseases. They have proven useful in a clinical setting to establish diagnosis, estimate prognosis, follow disease progression, alter therapy, and initiate new investigations. Cellular and molecular biologists have used autoantibodies as probes to identify molecules involved in key cellular processes. One of the most interesting sets of autoantibodies are those that target antigens within the…
20 Citations
Antibodies to Mitotic Spindle Apparatus: Clinical Significance of NuMA and HsEg5 Autoantibodies
- Medicine, BiologyJournal of Clinical Immunology
- 2008
Although both anti-mitotic spindle apparatus antibodies are not associated to a defined autoimmune pathology, the presence of NuMA antibodies, mainly at high titers, may be an indication for a more extensive screening of CTD.
Autoimmunity against hNinein, a human centrosomal protein, in patients with rheumatoid arthritis and systemic lupus erythematosus.
- Biology, MedicineMolecular medicine reports
- 2011
Results showed that autoepitopes on autoantigen hNinein are restricted to the N-terminal region and that a more significant proportion of RA patients exhibited centrosome reactivity.
Prevalence of Anticentromere F Protein Autoantibodies in 347 Patients with Non‐Hodgkin's Lymphoma
- Medicine, BiologyAnnals of the New York Academy of Sciences
- 2005
It is demonstrated that a significant incidence of anti‐CENP‐F aAbs is observed, before any treatment, in some histological subgroups of NHL patients, which indicates the usefulness of anti-CenP‐P aAbs as a marker for some NHL subgroups.
Human autoantibodies as reagents in biomedical research
- Biology, MedicineModern rheumatology
- 2003
This review highlights the uses of autoantibodies that may have limited diagnostic or prognostic utility, but are nonetheless novel reagents in the prosecution of molecular cell biology.
Uncommon patterns of antinuclear antibodies recognizing mitotic spindle apparatus antigens and clinical associations
- Medicine, BiologyMedicine
- 2018
In a large cohort of ANA determinations, uncommon patterns were found in around 1% of cases, and the most frequent anti-MSA patterns found were NuMA and MSA-2.
Clinical significance of rare serum autoantibodies in rheumatic diseases: a systematic literature review
- Medicine, BiologyJournal of Laboratory and Precision Medicine
- 2018
The main features associated to specific autoantibodies that are rarely identified in rheumatic disease are focused on, to increase the awareness and scientific knowledge on these autoantIBodies in different ethnic groups worldwide.
RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability.
- Biology, ChemistryMolecular biology of the cell
- 2003
It is demonstrated that a subset of cellular RHAMM localizes to the centrosome and functions in the maintenance of spindle integrity and provides a potential mechanism for this function in that RHAMm may cross-link centrosomal microtubules, through a direct interaction withmicrotubules and an association with dynein.
Bicaudal D2 is a novel autoantibody target in systemic sclerosis that shares a key epitope with CENP-A but has a distinct clinical phenotype.
- Biology, MedicineAutoimmunity reviews
- 2018
Prevalence and pattern of antinuclear autoantibodies in 347 patients with non‐Hodgkin's lymphoma
- Medicine, BiologyBritish journal of haematology
- 2003
A significant incidence of ANA is demonstrated before any treatment in NHL occurrence, which seems to be higher in some histological subgroups with particular ANA, such as ANA directed against mitotic proteins or mitotic‐associated proteins.
Anti-NuMA1 and anti-NuMA2 (anti-HsEg5) antibodies: Clinical and immunological features: A propos of 40 new cases and review of the literature.
- Medicine, BiologyAutoimmunity reviews
- 2010
References
SHOWING 1-10 OF 98 REFERENCES
Two major autoantigen-antibody systems of the mitotic spindle apparatus.
- Biology, MedicineArthritis and rheumatism
- 1996
NuMA protein and a 116-kd protein are the major targets of the autoimmune response in the mitotic apparatus, since most of the selected sera (based on IIF staining of theMitotic spindles and poles) recognized 1 of these 2 antigens.
The spindle kinesin-like protein HsEg5 is an autoantigen in systemic lupus erythematosus.
- Biology, MedicineArthritis and rheumatism
- 1996
Autoantibodies to HsEg5 are found in a lower frequency than NuMA in sera that demonstrate the MSA pattern of staining and appear to be specifically associated with SLE.
Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology.
- Biology, MedicineAdvances in immunology
- 1989
NuMA protein is a human autoantigen.
- Biology, MedicineArthritis and rheumatism
- 1984
Using immunoblot analysis, it is demonstrated that the autoantibodies that decorate the mitotic spindle poles are specific for the NuMA protein, which concludes that the Numa protein is a human autoantigen.
Fibrillarin: a new protein of the nucleolus identified by autoimmune sera
- Biology, MedicineBiology of the cell
- 1985
Fibrillarin is a widely occurring basic nonhistone nucleolar protein whose location and nuclease sensitivity may indicate some structural and/or functional role in the rDNA‐containing dense fibrillar and fibrillsar center regions of the nucleolus.
Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma
- Biology, MedicineChromosoma
- 2004
Examination of “preimmune” serum samples from a patient who progressively developed the symptoms of scleroderma CREST over a period of several years shows that these patients make antibody species recognizing at least three distinct epitopes on C ENP-B and two on CENP-C.
Anticentromere antibodies in subjects with no apparent connective tissue disease.
- Medicine, BiologyAnnals of the rheumatic diseases
- 1993
It is suggested that a positive result for ACA does not always indicate the presence of a connective tissue disease.
Autoantibodies to the centrosome (centriole) react with determinants present in the glycolytic enzyme enolase.
- Biology, MedicineJournal of immunology
- 1991
This work has studied autoantibodies from patients that react with the centrosome (centriole) region of the cell and found by immunoblotting techniques that these antibodies react with a 48-kDa protein.
Immunocytogenetics. IV. Human autoantibodies to heterochromatin-associated proteins.
- BiologyCytogenetics and cell genetics
- 1990
A novel class of human autoantibodies with immunological affinity for constitutive heterochromatin is reported, which represents a major nonhistone component of the mitotic chromosome scaffold and the interphase nuclear matrix.