Autoantibodies to components of the mitotic apparatus

@article{Rattner2004AutoantibodiesTC,
  title={Autoantibodies to components of the mitotic apparatus},
  author={Jerome B. Rattner and Gary J. Mack and Marvin J. Fritzler},
  journal={Molecular Biology Reports},
  year={2004},
  volume={25},
  pages={143-155}
}
Autoantibodies directed to a variety of cellular antigens and organelles are a feature of autoimmune diseases. They have proven useful in a clinical setting to establish diagnosis, estimate prognosis, follow disease progression, alter therapy, and initiate new investigations. Cellular and molecular biologists have used autoantibodies as probes to identify molecules involved in key cellular processes. One of the most interesting sets of autoantibodies are those that target antigens within the… 

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TLDR
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References

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TLDR
NuMA protein and a 116-kd protein are the major targets of the autoimmune response in the mitotic apparatus, since most of the selected sera (based on IIF staining of theMitotic spindles and poles) recognized 1 of these 2 antigens.

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TLDR
Autoantibodies to HsEg5 are found in a lower frequency than NuMA in sera that demonstrate the MSA pattern of staining and appear to be specifically associated with SLE.

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Antibodies against RNA polymerase I were associated with diffuse scleroderma of short duration, which was characterized by a high prevalence of internal organ involvement, including renal crisis, and anti-U3 RNP antibodies had ahigh prevalence in men with significantly less joint involvement, compared with ANoA-negative patients.
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