Autoantibodies to components of the mitotic apparatus

@article{Rattner2004AutoantibodiesTC,
  title={Autoantibodies to components of the mitotic apparatus},
  author={Jerome B. Rattner and Gary J. Mack and Marvin J. Fritzler},
  journal={Molecular Biology Reports},
  year={2004},
  volume={25},
  pages={143-155}
}
Autoantibodies directed to a variety of cellular antigens and organelles are a feature of autoimmune diseases. They have proven useful in a clinical setting to establish diagnosis, estimate prognosis, follow disease progression, alter therapy, and initiate new investigations. Cellular and molecular biologists have used autoantibodies as probes to identify molecules involved in key cellular processes. One of the most interesting sets of autoantibodies are those that target antigens within the… 
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20 Citations
Background Citations
8
Methods Citations
1

20 Citations

Antibodies to Mitotic Spindle Apparatus: Clinical Significance of NuMA and HsEg5 Autoantibodies

TLDR
Although both anti-mitotic spindle apparatus antibodies are not associated to a defined autoimmune pathology, the presence of NuMA antibodies, mainly at high titers, may be an indication for a more extensive screening of CTD.

Autoimmunity against hNinein, a human centrosomal protein, in patients with rheumatoid arthritis and systemic lupus erythematosus.

TLDR
Results showed that autoepitopes on autoantigen hNinein are restricted to the N-terminal region and that a more significant proportion of RA patients exhibited centrosome reactivity.

Prevalence of Anticentromere F Protein Autoantibodies in 347 Patients with Non‐Hodgkin's Lymphoma

TLDR
It is demonstrated that a significant incidence of anti‐CENP‐F aAbs is observed, before any treatment, in some histological subgroups of NHL patients, which indicates the usefulness of anti-CenP‐P aAbs as a marker for some NHL subgroups.

Human autoantibodies as reagents in biomedical research

TLDR
This review highlights the uses of autoantibodies that may have limited diagnostic or prognostic utility, but are nonetheless novel reagents in the prosecution of molecular cell biology.

Uncommon patterns of antinuclear antibodies recognizing mitotic spindle apparatus antigens and clinical associations

TLDR
In a large cohort of ANA determinations, uncommon patterns were found in around 1% of cases, and the most frequent anti-MSA patterns found were NuMA and MSA-2.

Clinical significance of rare serum autoantibodies in rheumatic diseases: a systematic literature review

TLDR
The main features associated to specific autoantibodies that are rarely identified in rheumatic disease are focused on, to increase the awareness and scientific knowledge on these autoantIBodies in different ethnic groups worldwide.

RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability.

TLDR
It is demonstrated that a subset of cellular RHAMM localizes to the centrosome and functions in the maintenance of spindle integrity and provides a potential mechanism for this function in that RHAMm may cross-link centrosomal microtubules, through a direct interaction withmicrotubules and an association with dynein.

Bicaudal D2 is a novel autoantibody target in systemic sclerosis that shares a key epitope with CENP-A but has a distinct clinical phenotype.

Prevalence and pattern of antinuclear autoantibodies in 347 patients with non‐Hodgkin's lymphoma

TLDR
A significant incidence of ANA is demonstrated before any treatment in NHL occurrence, which seems to be higher in some histological subgroups with particular ANA, such as ANA directed against mitotic proteins or mitotic‐associated proteins.

Non-membranous granular organelle consisting of PCM-1: subcellular distribution and cell-cycle-dependent assembly/disassembly

TLDR
It is shown by immunofluorescence microscopy that pericentriolar material 1 (PCM-1) granules are not only concentrated around centrioles but also scattered throughout the cytoplasm in various types of mouse cells, suggesting that this self-aggregation is regulated in a cell-cycle-dependent manner.

References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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