Autoantibodies to components of the mitotic apparatus

@article{Rattner2004AutoantibodiesTC,
  title={Autoantibodies to components of the mitotic apparatus},
  author={Jerome B. Rattner and Gary J. Mack and Marvin J. Fritzler},
  journal={Molecular Biology Reports},
  year={2004},
  volume={25},
  pages={143-155}
}
Autoantibodies directed to a variety of cellular antigens and organelles are a feature of autoimmune diseases. They have proven useful in a clinical setting to establish diagnosis, estimate prognosis, follow disease progression, alter therapy, and initiate new investigations. Cellular and molecular biologists have used autoantibodies as probes to identify molecules involved in key cellular processes. One of the most interesting sets of autoantibodies are those that target antigens within the… 
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TLDR
It is demonstrated that a subset of cellular RHAMM localizes to the centrosome and functions in the maintenance of spindle integrity and provides a potential mechanism for this function in that RHAMm may cross-link centrosomal microtubules, through a direct interaction withmicrotubules and an association with dynein.
Prevalence and pattern of antinuclear autoantibodies in 347 patients with non‐Hodgkin's lymphoma
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A significant incidence of ANA is demonstrated before any treatment in NHL occurrence, which seems to be higher in some histological subgroups with particular ANA, such as ANA directed against mitotic proteins or mitotic‐associated proteins.
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References

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TLDR
NuMA protein and a 116-kd protein are the major targets of the autoimmune response in the mitotic apparatus, since most of the selected sera (based on IIF staining of theMitotic spindles and poles) recognized 1 of these 2 antigens.
The spindle kinesin-like protein HsEg5 is an autoantigen in systemic lupus erythematosus.
TLDR
Autoantibodies to HsEg5 are found in a lower frequency than NuMA in sera that demonstrate the MSA pattern of staining and appear to be specifically associated with SLE.
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TLDR
Using immunoblot analysis, it is demonstrated that the autoantibodies that decorate the mitotic spindle poles are specific for the NuMA protein, which concludes that the Numa protein is a human autoantigen.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
A novel class of human autoantibodies with immunological affinity for constitutive heterochromatin is reported, which represents a major nonhistone component of the mitotic chromosome scaffold and the interphase nuclear matrix.
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