Autoantibodies to beta1-adrenoceptors in human chronic periodontitis induce overexpression of fibroblast CD40 and trigger prostaglandin E2 generation.

@article{SterinBorda2009AutoantibodiesTB,
  title={Autoantibodies to beta1-adrenoceptors in human chronic periodontitis induce overexpression of fibroblast CD40 and trigger prostaglandin E2 generation.},
  author={Leonor Sterin-Borda and C{\'e}sar Furl{\'a}n and Enri S. Borda},
  journal={Journal of periodontal research},
  year={2009},
  volume={44 3},
  pages={330-7}
}
BACKGROUND AND OBJECTIVE Autoimmune mechanisms may contribute to the pathogenesis of periodontal disease. Autoantibodies with the potential to bind and activate beta(1)-adrenoceptors (beta(1)-AR) of human gingival fibroblasts were studied to provide evidence of altered humoral immune response in chronic periodontal disease. MATERIAL AND METHODS Flow cytometry and enzyme-linked immunosorbent assay using cell culture-adherent gingival fibroblasts and/or their purified membranes and/or a… CONTINUE READING