Autoantibodies to a 128-kd synaptic protein in three women with the stiff-man syndrome and breast cancer.

@article{Folli1993AutoantibodiesTA,
  title={Autoantibodies to a 128-kd synaptic protein in three women with the stiff-man syndrome and breast cancer.},
  author={Franco Folli and Michele Solimena and R Cofiell and M Austoni and G. Tallini and Giuliano Fassetta and David Bates and Niall E F Cartlidge and Gian Franco Bottazzo and Giovanni Piccolo and Pietro De Camilli},
  journal={The New England journal of medicine},
  year={1993},
  volume={328 8},
  pages={546-51}
}
BACKGROUND The stiff-man syndrome is a rare disease of the central nervous system characterized by progressive rigidity of the body musculature. Autoantibodies directed against glutamic acid decarboxylase are present in about 60 percent of patients with the syndrome. In this group, there is a striking association of the stiff-man syndrome with organ-specific autoimmune diseases, primarily insulin-dependent diabetes mellitus. METHODS We studied three women with the stiff-man syndrome and… CONTINUE READING

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