Autoantibodies to Plasminogen and Their Role in Tumor Diseases


Plasma level of IgG autoantibodies to plasminogen was measured by ELISA in patients with benign prostatic hyperplasia (n=25), prostatic cancer (n=17), lung cancer (n=15), and healthy volunteers (n=44). High levels of IgG to plasminogen were found in 2 (12%) of 17 healthy women, in 1 (3.6%) of 27 specimens in a healthy man, in 17 (68%) of 25 specimens in prostatic cancer, in 10 (59%) of 17 specimens in lung cancer, and in 5 (30%) of 15 specimens in benign prostatic hyperplasia. Comparison of plasma levels of anti-plasminogen IgG by affinity chromatography showed 3-fold higher levels in patients with prostatic cancer vs. healthy men.

DOI: 10.1007/s10517-015-2792-1

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@article{Goufman2015AutoantibodiesTP, title={Autoantibodies to Plasminogen and Their Role in Tumor Diseases}, author={Eugene I Goufman and Volodya Yakovlev and Natalia B Tikhonova and Roza B Aisina and Konstantin N. Yarygin and Liliya Mukhametova and Karina Gershkovich and Dmitry A Gulin}, journal={Bulletin of Experimental Biology and Medicine}, year={2015}, volume={158}, pages={493-496} }