Autoantibodies to OxLDL fail to alter the clearance of injected OxLDL in apolipoprotein E-deficient mice.

Abstract

This study tests the hypothesis that autoantibodies to oxidation epitopes on oxidized LDL (OxLDL) promote the clearance of OxLDL from the plasma. Human LDL (hLDL) was injected into immune-competent apolipoprotein E-deficient (apoE(-/-)) mice and immune-deficient apoE(-/-)/recombination-activating gene-deficient mice that lack mature T and B cells and thus… (More)

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Cite this paper

@article{Reardon2004AutoantibodiesTO, title={Autoantibodies to OxLDL fail to alter the clearance of injected OxLDL in apolipoprotein E-deficient mice.}, author={Catherine A. Reardon and Elizabeth Ruth Miller and Lydia Blachowicz and John R Lukens and Christoph J. Binder and Joseph L. Witztum and Godfrey S. Getz}, journal={Journal of lipid research}, year={2004}, volume={45 7}, pages={1347-54} }