Autoantibodies to MOG in a distinct subgroup of adult multiple sclerosis

  title={Autoantibodies to MOG in a distinct subgroup of adult multiple sclerosis},
  author={Melania Spadaro and Lisa Ann Gerdes and Markus Krumbholz and B Ertl-Wagner and Franziska Sabrina Thaler and Elisabeth Schuh and Imke Metz and Astrid Blaschek and Andrea Dick and Wolfgang Br{\"u}ck and Reinhard Hohlfeld and Edgar Meinl and Tania Kuempfel},
  booktitle={Neurology(R) neuroimmunology & neuroinflammation},
OBJECTIVES To evaluate the presence of antibodies to conformation-intact myelin oligodendrocyte glycoprotein (MOG) in a subgroup of adult patients with clinically definite multiple sclerosis (MS) preselected for a specific clinical phenotype including severe spinal cord, optic nerve, and brainstem involvement. METHODS Antibodies to MOG were investigated using a cell-based assay in 3 groups of patients: 104 preselected patients with MS (group 1), 55 age- and sex-matched, otherwise unselected… CONTINUE READING
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