Autoantibodies to GP2, the major zymogen granule membrane glycoprotein, are new markers in Crohn's disease.

@article{Roggenbuck2011AutoantibodiesTG,
  title={Autoantibodies to GP2, the major zymogen granule membrane glycoprotein, are new markers in Crohn's disease.},
  author={D. Roggenbuck and D. Reinhold and T. Wex and A. Goihl and U. von Arnim and P. Malfertheiner and T. Buettner and T. Porstmann and Silvia Porstmann and B. Liedvogel and D. Bogdanos and M. Laass and K. Conrad},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2011},
  volume={412 9-10},
  pages={
          718-24
        }
}
  • D. Roggenbuck, D. Reinhold, +10 authors K. Conrad
  • Published 2011
  • Chemistry, Medicine
  • Clinica chimica acta; international journal of clinical chemistry
  • BACKGROUND Crohn's disease (CD) is an inflammatory bowel disease (IBD) characterized by reactivity against microbial and self antigens. Zymogen granule glycoprotein 2 (GP2) was identified as the major autoantigen of CD-specific pancreatic autoantibodies (PAB). METHODS Human GP2 was expressed in the Spodoptera frugiperda 9 (Sf9) cell line using the baculovirus system, purified by Ni-chelate chromatography, and used as antigen for anti-GP2 IgA and IgG assessment by enzyme-linked immunosorbent… CONTINUE READING
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