Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome.

  title={Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome.},
  author={Michele Solimena and Franco Folli and R Aparisi and Guido Pozza and Pietro De Camilli},
  journal={The New England journal of medicine},
  volume={322 22},
Stiff-man syndrome is a rare disorder of the central nervous system of unknown pathogenesis. We have previously reported the presence of autoantibodies against glutamic acid decarboxylase (GAD) in a patient with stiff-man syndrome, epilepsy, and insulin-dependent diabetes mellitus. GAD is an enzyme selectively concentrated in neurons secreting the neurotransmitter gamma-aminobutyric acid (GABA) and in pancreatic beta cells. We subsequently observed autoantibodies to GABA-ergic neurons in 20 of… CONTINUE READING
Highly Influential
This paper has highly influenced 22 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 172 extracted citations

Cancer Neurology in Clinical Practice

Springer International Publishing • 2018
View 12 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…