Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome.

@article{Solimena1990AutoantibodiesTG,
  title={Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome.},
  author={Michele Solimena and Franco Folli and R Aparisi and Guido Pozza and Pietro De Camilli},
  journal={The New England journal of medicine},
  year={1990},
  volume={322 22},
  pages={1555-60}
}
Stiff-man syndrome is a rare disorder of the central nervous system of unknown pathogenesis. We have previously reported the presence of autoantibodies against glutamic acid decarboxylase (GAD) in a patient with stiff-man syndrome, epilepsy, and insulin-dependent diabetes mellitus. GAD is an enzyme selectively concentrated in neurons secreting the neurotransmitter gamma-aminobutyric acid (GABA) and in pancreatic beta cells. We subsequently observed autoantibodies to GABA-ergic neurons in 20 of… CONTINUE READING
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